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피부과 전공의사들을 통해 피나스테리드 복용과 우울감 간에 직접적인 인과관계가 밝혀진 바 없다는 점이 알려졌기 때문이다. 실제 다수인 의료진들은 약 복용 보다는 탈모 자체로 인한 우울감 혹은 심리적 요인에 의해 생기는 부작용인 ‘노시보 효과 가능성을 지적하고 있다.
실험진은 그 이유를 세포 밖 환경, 세포외기질(ECM)과 세포를 연결하는 구조인 헤미데스모좀에서 찾았다. 헤미데스모좀은 수많은 단백질로 이뤄져 있어 세포와 세포외기질을 뻣뻣하게 연결하고, 세포가 정상적인 기능을 하는 데 도움을 준다고 알려져 있다.
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